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Fig. 1 | Journal of Experimental & Clinical Cancer Research

Fig. 1

From: PPP1R26 drives hepatocellular carcinoma progression by controlling glycolysis and epithelial-mesenchymal transition

Fig. 1

PPP1R26 is upregulated in HCC tumor tissues and related to a worse prognosis. A Staining intensity of PPP1R26 in HCC tissues is classified as negative staining (−, score 0), weak staining (+, score 1–4), moderate staining (++, score 5–8), and strong staining (+++, score 9–12) (left); IHC score of PPP1R26 in normal and HCC tissues in PUCH cohort (middle); PPP1R26 mRNA expression in TCGA HCC tissues (right). Scale bars represent 50 μm. B Staining scores of PPP1R26 in HCC tissues for each BCLC stage, the negative or positive of microscopic vascular invasion, survival status and the absence or presence of recurrence. C The percentage of the patients with PPP1R26 negative and positive expression in each group according to BCLC stages, survival, recurrence, and microscopic vascular invasion. D Kaplan-Meier survival curves of overall survival (OS) and disease-free survival (DFS) time in patients with positive or negative PPP1R26 expression. E Kaplan-Meier analysis of OS and DFS in 125 HCC patients stratified by PPP1R26 (−), PPP1R26 (+), PPP1R26 (++) and PPP1R26 expression (+++). Data information: In (B-C), data are presented as mean ± SEM. Statistical significance was assessed using two-tailed t-tests (A, B & C) or one-way ANOVA with post hoc analysis LSD test (B & C). In (D-E), P values were determined by log-rank test. *P < 0.05, **P < 0.01, ***P < 0.001 and ****P < 0.0001

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