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Fig. 3 | Journal of Experimental & Clinical Cancer Research

Fig. 3

From: ZMAT1 acts as a tumor suppressor in pancreatic ductal adenocarcinoma by inducing SIRT3/p53 signaling pathway

Fig. 3

Over-expression of ZMAT1 arrests the cell cycle in Pancreatic Ductal Adenocarcinoma (PDAC) cells. A Gene Ontology (GO) enrichment analysis of ZMAT1 based on TCGA cohort. B Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis of ZMAT1 based on TCGA cohort. C-E Flow cytometry showed over-expression of ZMAT1 triggered G2/S blockade in SW1990 cells (C), while depletion of ZMAT1 increased the percentage of S phase in BXPC-3 (D) and Capan-2 cells (E). FH Western blot showed over-expression of ZMAT1 up-regulated p21 and decreased CDK2 and CCNA2 in SW1990 cells (F), whereas ZMAT1 knockdown declined p21 and increased CDK2 and CCNA2 in BXPC-3 (G) and Capan-2 cells (H). All * P-value < 0.05, ** P-value < 0.01, *** P-value < 0.001. P-values were assessed using two-tailed t-tests in C-E. All figures represent mean ± SD from three independent experiments

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