Skip to main content
Fig. 4 | Journal of Experimental & Clinical Cancer Research

Fig. 4

From: Direct interaction of TrkA/CD44v3 is essential for NGF-promoted aggressiveness of breast cancer cells

Fig. 4

CD44v3 mimetic peptide 4 inhibits MDA-MB-231 breast cancer cell growth and migration/invasion. Clonogenic MDA-MB-231 cell growth was measured after 10 days in the presence of a scramble peptide (SP) or CD44v3 mimetic peptide (P4) (A, B). The elongation factor (length-to-width ratio) was assessed after 10 days in the presence or absence of NGF (C, D, E). Migration assays were performed using Ibidi devices 24 h after treatment (H, I). Invasion through collagen 1 was measured by the Transwell assay 16 h after treatment (J, K). Statistical analyses were performed using one-way ANOVA followed by Bonferroni’s posttest. The error bars represent the standard error of the mean (S.E.M.); * p < 0.05, ** p < 0.01, *** p < 0.001, **** p < 0.0001; ns, not significant

Back to article page