Fig. 8

Schematic representation of the TrkA-CD44v3 interaction induced by NGF. (1) In the presence of NGF, TrkA interacts with CD44v3 variant 3 at histone residue H112. This interaction is the basis for phospho-independent TrkA signaling. It involves the p115 RhoGEF/RhoA/ROCK1 signaling cascade to induce tumor development. (2) In the presence of CD44v3 4 mimetic peptide (P4), the TrkA/CD44v3 complex cannot form, and phosphorescent-independent TrkA signaling through RhoA is inhibited. This results in decreased tumor development and metastatic capabilities