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Fig. 2 | Journal of Experimental & Clinical Cancer Research

Fig. 2

From: Stanniocalcin 1 promotes metastasis, lipid metabolism and cisplatin chemoresistance via the FOXC2/ITGB6 signaling axis in ovarian cancer

Fig. 2

STC1 promotes metastasis and lipid metabolism in vitro. A WB results of the STC1 expression levels in different OC cell lines. B STC1-knockdown cell lines were established with Skov3-ip1 and Hey cells, and the transfection efficiency was confirmed by WB assays. C PCA of data from untargeted relative quantitative lipidomic analysis. D Volcano plot of individual lipid species significantly up- or down- regulated in the NC group versus the STC1-sh1 and STC1-sh2 groups in Hey cell lines (lipids with a P value < 0.05 and a fold change (FC) > 1.5 or < 0.67 were indicated in blue or red, respectively). E Correlation analysis of the ten lipid classes. F A heat map of significant differences in the variables among the NC, STC1-sh1 and STC1-sh2 groups of Hey cells. The variables were ranked by ANOVA. G TEM images of OC cells in Skov3-ip1 and Hey cell lines (red arrow: mitochondria). H ORO staining of OC cells in Skov3-ip1 and Hey cell lines (red arrow: TGs). (Data are shown as the mean ± SD values. Significance was calculated using Student’s t test. *, P < 0.05; **, P < 0.01; ***, P < 0.001; ****, P < 0.0001.)

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