Fig. 6
STC1 promotes metastasis, lipid metabolism and DDP chemoresistance in vivo. A The model of cell injection into nude mice. B-C Luciferase expression was detected in the mouse model. The NC group showed significantly higher flux than the NC + DDP group, STC1-sh1 group and STC1-sh1 + DDP group. D The NC group showed significantly larger tumors than the NC + DDP group, STC1-sh1 group and STC1-sh1 + DDP group. E The tumor weights and tumor volumes in the four groups. F-G The NC groups had metastatic tissues in the liver, spleen and intestine. H H&E staining of metastatic tissues (liver, spleen and intestine) in the NC groups. I Representative WB results of UCP1, TOM20 and perilipin1 in tissues from two mouse tumors generated by injection of the two cell lines. J IF analysis showed the relationship between STC1 and UCP1 in tissues from two mouse tumors generated by injection of the cell lines. (Data are shown as the mean ± SD values. Significance was calculated using Student’s t test. *, P < 0.05; **, P < 0.01; ***, P < 0.001; ****, P < 0.0001.)