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Fig. 4 | Journal of Experimental & Clinical Cancer Research

Fig. 4

From: OVOL2 impairs RHO GTPase signaling to restrain mitosis and aggressiveness of Anaplastic Thyroid Cancer

Fig. 4

OVOL2 alters mitosis markers localization and extracellular adhesion proteins. A-F Immunofluorescence staining of AURKB A, B, INCENP C, D and BOREALIN E, F (red) in 8505c and 8305c EV and OVOL2-expressing cells. Nuclei are stained with DAPI (blue). Scale bar 50 µm. G Cytofluorimetric analysis for the assessment of integrin αV-β5 positivity in OVOL2-8505c cells normalized on EV cells. Histogram represents mean and SD of two independent biological replicates *p < 0,05, **p < 0,005. H) Western blot analysis of the levels of FAK in 8505c cells at different time points upon OVOL2 induction, compared to EV

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