Table 1 LncRNAs mediate DNA methylation in cancer

TINCR

Recruit

DNMT1

miR-503-5p

Regulate EGFR expression

BC

[42]

MROS-1

Recruit

DNMT3A

PRUNE2

Nodal metastases

OC

[43]

HOTAIR

Recruit

DNMT1

PTEN

Cell proliferation, invasion and migration

CML

[44]

LINC00887

Recruit

DNMT1

CA9

Suppress oncogenic CA9

TSCC

[45]

LINC00472

Recruit

DNMTs

MCM6

Inhibited tumor growth and metastasis

TNBC

[46]

LINC01270

Recruit

DNMTs

GSTP1

Promote tumorigenesis and drug resistance

EC

[47]

HOTAIR

Recruit

DNMTs

MTHFR

chemoresistance

EC

[48]

ADAMTS9-AS2

Recruit

DNMT1/3

CDH3

Inhibits proliferation, invasion, and migration

EC

[49]

IRAIN

Recruit

DNMT1/3

VEGFA

Suppresses tumor growth

RC

[50]

PVT1

Recruit

DNMT1

miR-18b-5p

Promotes proliferation

GBC

[51]

BZRAP1-AS1

Recruit

DNMT3b

THBS1

Promotes angiogenesis

HCC

[52]

PYCARD-AS1

Recruit

DNMT1, G9a

PYCARD

Regulates apoptosis

BC

[53]

MIR210HG

Recruit

DNMT1

CACNA2D2

Promotes proliferation and invasion

NSCLC

[54]

HAGLR

Recruit

DNMT1

E2F1

Suppresses tumor growth

LUAD

[55]

DACOR1

Recruit

DNMT1

Genome-wide

CRC

[56, 57]

PVT1

Recruit

DNMT1

BNIP3

Promotes cell proliferation

GC

[58]

MALAT1

Mitochondrial DNA

Control metabolic Reprogramming

HCC

[59]

HOTAIR

Upregulate

DNMT3b

PTEN

Doxorubicin resistance

AML

[60]

RP11-159K7.2

Upregulate

DNMT3A

Promotes cell growth and invasion

LSCC

[61]

GAS5

Down-regulate

DNMTs

miR-424

Suppresses multiple malignant phenotypes

Glioma

[62]

lnc-OIP5-AS1

Upregulate

DNMT1

pre-miR-218–1

Promote cell motility and proliferation

KS

[63]

Linc-GALH

Ubiquitinate

DNMT1

Gankyrin

Promotes metastasis

HCC

[64]

LUCAT1

Inhibits ubiquitination

DNMT1

tumor-suppressor genes

Promotes tumor formation and metastasis

ESCC

[65]

HOTAIR

Upregulate (via EZH2)

DNMTs

miR-122

Activate Cyclin G1 and promote tumorigenicity

HCC

[66]

HOTAIR

Upregulate

DNMT1/3B

HOXA1

Multidrug resistance

SCLC

[67]

H19

Upregulate

TET3

MED12

Promotes cell proliferation

UL

[68]

DBCCR1-003

Sequestrate

DNMT1

DBCCR1

Inhibits cell growth

BCa

[69]

TTTY15

Sequestrate

DNMT3A

TBX4

Suppresses metastasis

NSCLC

[70]

HOTAIRM1

Sequestrate

G9a/EZH2/ DNMTs

HOXA1

Promotes tumor growth and invasion

GBM

[71]

91H

Repel

DNMTs

H19/IGF2 locus

Promotes tumorigenesis

BC

[72]

HOTAIR

Recruit (via EZH2)

HOXA1

Multidrug resistance

SCLC

[73]

SNHG3

Recruit (via EZH2)

MED18

Promotes cell migration and invasion

GC

[74]

HOXB13-AS1

Recruit (via EZH2)

DNMT3B

HOXB13

Promotes cell proliferation

Glioma

[75]

Lnc-LALC

Recruit (via EZH2)

DNMTs

LZTS1

Liver metastasis

CRC

[76]

HOTAIR

Recruit (via EZH2)

DNMT1

miR-454-3p

Promotes tumor growth

CS

[77]

GIHCG

Recruit (via EZH2)

DNMT1

miR-200b/a/429

Promotes tumor growth and metastasis

HCC

[78]

LINC00630

Restrict (via EZH2)

DNMT3B

BEX1

Suppresses cell apoptosis and promotes radio-resistance

CRC

[79]

Lnc34a

Recruit (via PHB2)

DNMT3A

miR-34a

Promotes cell proliferation

CRC

[80]

H19

Inhibit (via inhibiting SAHH)

DNMT3b

Beclin1

Induces autophagy activation and tamoxifen resistance

BC

[81]

LINC00662

Regulate

MAT1A/ SAHH

Activates SAM-dependent oncogenes

HCC

[82]

SNHG6

Regulate (via miRNAs)

MAT1A, MAT2A

Genome-wide

HCC

[83]

H19

Inhibit (via inhibiting SAHH)

DNMTs

LINE-1

Benzo [a]pyrene (BaP) carcinogenesis

Lung cancer

[84]

MAGI2-AS3

Recruit

TET2

LRIG1

Inhibits the self-renewal of leukaemic stem cells

AML

[85]

SSTR5-AS1

Recruit

TET1

E-cadherin

Inhibits tumor progression and metastasis

LSCC

[86]

SATB2-AS1

Recruit (via GADD45A)

TETs

SATB2

Inhibits cell metastasis and regulates immune response

CRC

[87]