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Fig. 1 | Journal of Experimental & Clinical Cancer Research

Fig. 1

From: The multifaceted roles of cohesin in cancer

Fig. 1

Structure of the cohesin complex. The cohesin ring is composed of SMC1A, SMC3, RAD21, and STAG1/2. SMC proteins are long polypeptides that fold back on themselves to form a coiled-coil domain with a hinge domain at one end and an ATPase domain at the other. SMC1A and SMC3 form a V-shaped structure by interaction of their hinge domains. The N- and C-terminus of RAD21 interact with SMC3 and SMC1A respectively. The STAG1/2 subunit interacts with RAD21.The NIPBL/MAU2 dimer loads cohesin onto DNA, whereas WAPL/PDS5 release cohesin from chromosomes

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