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Fig. 3 | Journal of Experimental & Clinical Cancer Research

Fig. 3

From: The multifaceted roles of cohesin in cancer

Fig. 3

Chromosome imbalance and cancer. A Altered segregation of chromosomes harbor a proto-oncogene can lead to gene gain and proto-oncogene over-expression. B Knudson’s hypothesis foresees that two hits are required for the inactivation of a tumor suppressor gene. The first hit is an inactivating mutation on the suppressor gene. The second hit is the chromosome loss caused by cohesin dysfunction

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