Fig. 3From: The multifaceted roles of cohesin in cancerChromosome imbalance and cancer. A Altered segregation of chromosomes harbor a proto-oncogene can lead to gene gain and proto-oncogene over-expression. B Knudson’s hypothesis foresees that two hits are required for the inactivation of a tumor suppressor gene. The first hit is an inactivating mutation on the suppressor gene. The second hit is the chromosome loss caused by cohesin dysfunctionBack to article page