Table 2 Cohesin core subunits and its modulators in the COSMIC database
Gene | Samples | Mutations | Mutations/Samples (%) | Cancer Genes Census |
|---|---|---|---|---|
ESCO1 | 40,475 | 618 | 1.5 | No |
ESCO2 | 40,611 | 369 | 0.9 | No |
ESPL1 | 40,952 | 961 | 2.3 | No |
HDAC8 | 40,702 | 910 | 2.2 | No |
MAU2 | 40,484 | 473 | 1.2 | No |
NIPBL | 41,039 | 2019 | 4.9 | No |
PDS5A | 40,388 | 1094 | 2.7 | No |
PDS5B | 41,520 | 1399 | 3.4 | No |
PTTG1 | 40,832 | 130 | 0.3 | No |
RAD21 | 63,847 | 871 | 1.4 | YES |
SMC1A | 44,193 | 747 | 1.7 | YES |
SMC3 | 44,590 | 797 | 1.8 | No |
STAG1 | 41,564 | 2087 | 5.0 | YES |
STAG2 | 68,769 | 2321 | 3.4 | YES |
USP37 | 41,001 | 887 | 2.1 | No |
WAPL | 40,478 | 803 | 2.0 | No |