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Fig. 1 | Journal of Experimental & Clinical Cancer Research

Fig. 1

From: Flap endonuclease 1 and DNA-PKcs synergistically participate in stabilizing replication fork to encounter replication stress in glioma cells

Fig. 1

FEN1 Promotes DNA Replication Signaling Hyper-activation and Glioma Progression. a FEN1 expression was significantly elevated in glioma samples. b Overall survival of glioma patients with high and low FEN1 expression. c GSEA plot of DNA replication, cell cycle, and homologous recombination signatures in glioma samples. d GO indicates indicated a significant enrichment for multiple items of FEN1 associated with cellular progression including DNA replication and MCM complex in glioma samples e A correlation network plot of FEN1-related genes in glioma samples. f A PPI network of FEN1-related proteins. g, h Top 20 frequently mutated genes in FEN1 low and high expression groups. i, j The co-occurrence and mutually exclusive relationships between top frequently mutations in FEN1 low and high expression groups. k Relative mRNA level of lists of replisome factors in TMZ sensitive/resistant U87MG cells. l Volcano plot of DNA replication and repair-related genes in TMZ sensitive/resistant U87MG cells. Red dots indicate the up-regulated genes while blue dots indicate down-regulated genes in U87MG. R cells

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