Skip to main content
Fig. 5 | Journal of Experimental & Clinical Cancer Research

Fig. 5

From: A roadmap for translational cancer glycoimmunology at single cell resolution

Fig. 5

Roadmap towards novel glycan-based immunotherapy. Humanized in vitro and in vivo models are expected to hasten the translation of fundamental glycoimmunology research into glycan-based tools with theragnostic potential. Currently, the field heavily relies on short term in vitro co-cultures involving glycoengineered cell models and blood derived immune cells. Transgenic mouse models resulting from glycogenes editing have also been explored. The generalization of 3D systems, namely organoids, organs-on-a-chip, and humanized animal models will be of key importance to capture tumour heterogeneity and immune system contributions to tumour progression. The generalization of artificial intelligence approaches will also be decisive to integrate massive omics data into comprehensive models. We anticipate that such roadmap could speed the arrival of much needed novel therapeutic options, constituting valuable alternatives to current immunotherapies. 

Back to article page