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Fig. 4 | Journal of Experimental & Clinical Cancer Research

Fig. 4

From: Circular RNA circ-MTHFD1L induces HR repair to promote gemcitabine resistance via the miR-615-3p/RPN6 axis in pancreatic ductal adenocarcinoma

Fig. 4

MiR-615-3p reverses gemcitabine resistance of circ-MTHFD1L. A Quantitative RT-PCR (qRT-PCR) analysis of miR-615-3p in the two gemcitabine-resistant cell lines compared with their parental cells. B-E The proliferative ability of the indicated cells dealing with gemcitabine was investigated via colony formation assays (B, C) and CCK-8 assays (cell viability and IC50) (D, E). Representative colony formation images are shown (B), and the numbers of colonies were summarized (C). F Flow cytometry analysis of the cell cycle progression of the indicated cells dealing with gemcitabine was performed. Representative images and quantification of the results are presented. Data are shown as mean ± SD. *P < 0.05; **P < 0.01; ***P < 0.001, between the indicated groups

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