Fig. 2
Inhibition of CA IX/XII by SLC-0111 sensitizes HNSCC cells to Cis-Pt. Cell viability analysis of FaDu (A) and SCC-011 (B) cells grown under hypoxic conditions (1% O2) and treated with Cis-Pt (1 µM), SLC-0111 (100 µM) and combination of the two drugs for 72 h. Cell survival of FaDu (C) and SCC-011 (D) cells grown under hypoxic conditions (1% O2) and treated with Cis-Pt (1 µM), SLC-0111 (100 µM) and combination of the two drugs was assessed by colony formation assay cells. All the data are expressed as percentage considering the untreated control cells as 100%. Bars depict mean ± SD of three independent experiments. (***p < 0.0001; ** p < 0.001; *p < 0.01)