Skip to main content

Table 1 The substrates of TBK1 and their corresponding signaling pathways

From: The role of TBK1 in cancer pathogenesis and anticancer immunity

Pathways

Substrates

IRF3/7-IFN pathway

IRF3 at Ser339/386/396 [146,147,148,149,150,151]

IRF7 Ser471/472 [152, 153]

DDX3X at Thr542, Ser543 [42]

STAT3 at Ser754, 727 [72, 154]

STAT6 at Ser407, Tyr641 [155]

NF-κB signaling

PEL1 Ser76/293, Thr288 [156]

IKKβ at Ser177/181 [41]

NIK at Ser862 [78]

XIAP at Ser430 [157]

CYLD at Ser418 [158]

RIPK1 at Thr189 [74]

p65 NF-κB (RelA) at Ser536 [70, 159, 160]

cRel at Ser479/602 [70]

IkBα at Ser36 [41, 161]

Metadherin at Ser568 [142]

ACT1/TRAF3IP2 at Ser162/220/ 233/311 [162]

Mitotic regulators

PLK1 at Ser568, Thr210 [142]

CEP170 at multiple sites [80]

NuMA at multiple sites [80]

Cdc20 at Ser134 [163]

Cdh1 at Thr20, Ser39/42/58 /131/151 [163]

AKT-mTor signaling

AKT1 at Thr195/308, Ser378/ 473/476 [2]

Raptor at Ser877 [15]

mTor at Ser2159/2481 [68, 164]

S6K at T421/S424 [165]

Sec5 [69]

GSK3α at Ser21 [44]

SRC at Tyr179 [101]

Autophagy pathway

AMPKα1 at Ser459/476 [39], Thr172

LC3C at Ser93/96 [71]

GABARAP-L2 at Ser87/88 [71]

p62/SQSTM1 on Ser403/366 [4]

mLRRK2 at Ser910/935/995 [166]

OPTN at Ser177/473/513 [54, 167]

STX17 at Ser202 [73]

RAB7A at Ser72 [54]

Adaptor proteins

STING Ser324/326/358/366 [134, 168, 169]

TRIF at Ser210/212, Thr214 [169]

MAVS at Ser442 [169]

MVB12b at Ser222 [170]

TANK Ser49/126/178/208/228/257 [99]

TRAF2 at Ser11 [171]

Insulin/glucose signaling

IR at Ser994 [25]

PDE3B at Ser 318 [172]

Exo84 Ser8 [173]

Others

Tau at Ser214/324/356 [27]

HTT at Ser13/16 [28]

ERα at Ser-305 [174]

YAP1 at Thr110/114, Ser128/131

HDAC3 at Ser424 [59]