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Fig. 1 | Journal of Experimental & Clinical Cancer Research

Fig. 1

From: Identification of RNA-splicing factor Lsm12 as a novel tumor-associated gene and a potent biomarker in Oral Squamous Cell Carcinoma (OSCC)

Fig. 1

Lsm12 expression is upregulated in the model of OSCC tumorigenesis. a The position of Lsm12 gene on the chromosome and its transcription and translation products. Lsm12 belongs to Sm family which is involved in RNA splicing. b Histopathological images of normal epithelium, hyperplasia, mild/moderate dysplasia, papilloma and squamous cell carcinoma in the animal model of OSCC tumorigenesis. The papilloma is accompanied by severe dysplasia. Bar, 100 μm. c The clustergram of mRNA microarray showed genome-wide expression profiles in four squamous cell carcinoma tissues (purple), four papilloma tissues (dark blue), four dysplasia tissues (light green), four hyperplasia tissues (yellow) and two normal tissues (red). d Real time PCR results validated that Lsm12 expression at mRNA level was significantly upregulated in OSCC tissues compared with that in papilloma tissues (P < 0.01), which were consistent with the results of mRNA microarray data analysis

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