Fig. 5

Lsm12 regulates the expression and alternative splicing of genes. a Volcano plot showed 1032 DEGs including 592 upregulated and 440 downregulated genes induced by Lsm12 knockdown. The red dots represent the upregulated genes and the green dots represent the downregulated genes (≥2-fold, P < 0.05). b The top 20 significantly enriched DO categories include some oral and respiratory diseases. c The top 30 enriched GO items such as positive regulation of cell proliferation, positive regulation of angiogenesis, and immune response. d The enriched 17 pathways such as transcriptional misregulation in cancer. e Lsm12 knockdown induced alternative splicing events including SE, RI, A5SS and A3SS