Fig. 8

Schematic diagram depicting the mechanism by which miR-15b-5p affects the metastasis of GC. EVs from M2 macrophages can transfer miR-15b-5p to GC cells where it is upregulated and targets BRMS1 to inhibit its expression. The expression of DAPK1 is thus suppressed and the metastasis of GC cells is ultimately accelerated