Fig. 1From: Circulating cell free DNA and citrullinated histone H3 as useful biomarkers of NETosis in endometrial cancercitH3 staining is present in all endometrial tumor grades. IHC staining of endometrial FFPE tissues with anti-citH3 antibody observed by light microscopy, scale 30 um, 20 × objective. A Staining of citH3 in the leukocyte infiltrate in all EC grades (G1, G2, G3), ranging from low to high signal intensity. B Healthy subjects (HSs) are negative for the staining. C Box-plots of citH3 staining % in leucocytes infiltrate in 48 EC samples. Boxes extend from the 25th to 75th percentiles, the horizontal line in the box represent median. X indicates mean value. D Images of G2 and G3 EC tissues (40 × objective). Black arrows indicate citH3 release into the extracellular space. All scale bars indicate 30 mmBack to article page