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Fig. 2 | Journal of Experimental & Clinical Cancer Research

Fig. 2

From: CDC20 in and out of mitosis: a prognostic factor and therapeutic target in hematological malignancies

Fig. 2

Schematic representation of SAC activity. A Unattached or misaligned kinetochores activate the KMN network, leading to recruitment of SAC proteins and conformational change of MAD2 (closed form, C-MAD2). This allows to the formation of the MCC, which sequestrate CDC20 leading to mitotic arrest. B Properly attached kinetochores satisfy the SAC, which allow the onset of anaphase through release of CDC20 from MAD2 (open, form, O-MAD2) the interaction between CDC20 and APC/C. APC/CCDC20 complex promotes Cyclin B and Securin ubiquitination and degradation, starting sister chromatid separation

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