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Fig. 5 | Journal of Experimental & Clinical Cancer Research

Fig. 5

From: EIF4A3-regulated circ_0087429 can reverse EMT and inhibit the progression of cervical cancer via miR-5003-3p-dependent upregulation of OGN expression

Fig. 5

The tumour suppressor effect of circ_0087429 in cervical cancer can be reversed by miR-5003-3p. HeLa cells were transfected with pcDNA5.1-NC, pcDNA5.1-circ, pcDNA5.1-circ + mimics NC or pcDNA5.1-circ + miR mimics for subsequent detection. a-b. The expression of circ_0087429 and miR-5003-3p in each group was tested by qRT-PCR. c-g. CCK-8, EdU and colony formation assays were used to detect the proliferation ability of each group of cells. Scale bar, 50 μm. h-i. Wound healing assays determined the migration ability of each group of cells. Scale bar, 100 μm. j-k. Transwell invasion assays detected the invasion ability of each group of cells. Scale bar, 50 μm. **p < 0.01, ***p < 0.001

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