Fig. 10

Sox4 knockdown obviously weakened the induction of IL-6 on the tumor growth and inflammation in nude mouse xenografts of OSCC. SCC-15 cells processed with shSox4 or/and IL-6 were subcutaneously injected into nude mice. (A) After 3 weeks, groups of tumors were presented. (B) The volume of the tumor was counted in each group. (C) Immunohistochemical staining of Sox4, NLRP3, and Ki-67 expressions in each group. (D) Ki-67 positive cells were calculated. (E) ELISA kits were applied to analyze IL-1β and IL-18 levels in the serum of nude mice