Fig. 6

STAT3 could signally regulate Sox4 expression in a targeted manner. (A) Identification sites on STAT3 gene were exhibited. (B) Binding sites of STAT3 on Sox4 promoter and the sequence of mutations. (C) The regulatory relationship between STAT3 and Sox4 was certified with ChIP. (D) The targeted regulation of Sox4 by STAT3 was verified with Dual luciferase reporter gene assay. (E) DNA Pull-down was applied to test the regulatory correlation between STAT3 expression and Sox4 promoter. *** P < 0.001