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Fig. 3 | Journal of Experimental & Clinical Cancer Research

Fig. 3

From: TEAD4 functions as a prognostic biomarker and triggers EMT via PI3K/AKT pathway in bladder cancer

Fig. 3

EMT is a key factor contributing to poor prognosis in BLCA (A) Univariate and multivariate Cox analysis results of Clinical phenotype characters in TCGA-BLCA database (B) Time‐dependent ROC curve of BLCA prognostic model. The AUC was assessed at 1, 3 and 5 years. (C) GSEA results of the high-risk group versus low-risk group in prognostic model (P = 0.03, NES = 1.81). (D) NMF rank survey of unsupervised clustering results. (E) Consensus matrix heatmap of two clusters yielded by the unsupervised clustering. (F) Enrichment of EMT related gene sets in the two clusters yielded by the unsupervised clustering. (G) Boxplots showing the enrichment levels of EMT-related genes in Cluster1 and Cluster2 groups (H) Survival curves of patients from Cluster1 and Cluster2 (P = 0.02). (I) Scatter plot of the correlation between prognostic factors (FASN, IGFL2, PLOD1 and TEAD4) expression and EMT in BLCA

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