Fig. 1

GABPA is downregulated in ccRCC tumors and is associated with patient survival. A GABPA expression in tumors and matched noncancerous adjacent renal tissues (NTs) from 31 ccRCC patients. GABPA mRNA expression was determined using qPCR. B GABPA mRNA expression in ccRCC tumors and NTs from the TCGA cohort of patients. C The representative IHC staining images showed diminished GABPA expression at protein levels in the tumor (T) compared that in matched NT. Scale bar: 100 µm. D Higher GABPA expression is associated with longer overall survival (OS) in the TMA cohort of ccRCC patients. E and F Higher GABPA mRNA expression predicts longer OS and DFS in the TCGA cohort of ccRCC patients. G and H Multivariate analyses show the impacts of GABPA mRNA expression on OS and DFS in the TCGA cohort of ccRCC patients, respectively