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Fig. 7 | Journal of Experimental & Clinical Cancer Research

Fig. 7

From: GABPA-activated TGFBR2 transcription inhibits aggressiveness but is epigenetically erased by oncometabolites in renal cell carcinoma

Fig. 7

GABPA over-expression inhibits in vivo ccRCC metastasis and growth in xenograft mouse models. 786-O/GABPA and 786-O/Control cells were injected into nude mice via the tail vein and subcutaneously, respectively. Lungs and tumors were examined for metastasis and growth, respectively. (A-C) Significantly reduced numbers of tumor foci in lungs from mice injected with 786-O/GABPA cells via vein tail. A Tumor foci indicated by yellow arrows. B H & E staining of metastatic tumors in lungs from 786/control and 786/GABPA cells, respectively. Shown are representative images. Scale bars: 50 µm. C The number of tumors in lungs from two groups. D and E Defective tumor growth in mice subcutaneously injected with 786-O/GABPA cells. F IHC analyses of GABPA, TGFBR2 and Ki67 expression in tumors derived from 786-O/control and 786-O/GABPA cells. The images in insets were with bigger magnifications. Scale bars: 50 µm. G The work model for the GABPA-TGFβ signaling and relationship with oncometabolites during ccRCC development and progression

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