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Fig. 1 | Journal of Experimental & Clinical Cancer Research

Fig. 1

From: New molecular mechanisms in cholangiocarcinoma: signals triggering interleukin-6 production in tumor cells and KRAS co-opted epigenetic mediators driving metabolic reprogramming

Fig. 1

Proteomic analysis of bile in the rat TAA model of CCA development. a Schematic representation of the rat TAA model of CAA implemented in this study. c Pie chart showing the classification of proteins identified as differentially represented in bile from control and CCA bearing rats (30 weeks) according to their cellular localization. b Volcano plot (−log10 [p-value] and log2 [fold-change]) of the proteins found in bile from rats with CCA compared with control animals. d Principal component analysis (PCA) of bile proteomic data from control (Veh-1-4) and TTA (TAA-1-4) treated rats. e Ingenuity pathway analysis (IPA) of the differentially represented proteins between control and CCA bile samples identifying the top enriched categories of canonical pathways. Created with BioRender.com

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