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Fig. 5 | Journal of Experimental & Clinical Cancer Research

Fig. 5

From: New molecular mechanisms in cholangiocarcinoma: signals triggering interleukin-6 production in tumor cells and KRAS co-opted epigenetic mediators driving metabolic reprogramming

Fig. 5

Metabolic reprogramming in experimental CAA (rat TAA model) and human iCCA. a Expression of glucose metabolism-related genes in liver tissue samples from control rats (Vehicle), peritumour liver tissues and tumour tissues. *p < 0.05, **p < 0.01, ***p < 0.001. b Immunohistochemical analysis of PHGDH in liver tissue samples from control rats (Vehicle), peritumoural liver tissues and tumoural tissues. Representative images are shown. c Immunohistochemical analysis of PHGDH in human iCCA tissue samples. Representative images of tumours with 9, 6–4 and 0 PHGDH immunostaining scores are shown. Graphs show the distribution of PHGDH scores among all iCCA tissue samples and according to tumor grade (G1-G3)

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