Fig. 8
G9a inhibition reduces PHGDH expression in a mouse model of CCA. a Diagram showing the experimental model and the treatments applied (n = 6 mice per group). b Phgdh mRNA levels in the liver of wild type mice, JnkΔhepa mice, JnkΔhepa mice treated with CCl4 and diethylnitrosamine (DEN) (JnkΔhepa + CCl4 + DEN mice) and JnkΔhepa + CCl4 + DEN mice treated with CM-272 as indicated. **p < 0.01. c Immunohistochemical detection of PHGDH in liver tissue sections from mice treated as described in b. Representative images are shown. Created with BioRender.com