Fig. 10

Representative immunohistochemical patterns of TAZ and its interactors in human intrahepatic cholangiocarcinomas. Pronounced nuclear staining for TAZ in a cholangiocellular tumor (T), which is positive to the biliary marker CK19 and negative to the hepatocellular marker CPS1, is paralleled by faint immunoreactivity for activated/phosphorylated (p-)LATS1/2 and inactivated/phosphorylated (p-)TAZ. Note the robust immunoreactivity for p-LATS1/2 and p-TAZ in the neighboring non-tumorous liver tissue (ST). Original magnification: 100x; scale bar: 100 μm. Abbreviations: H&E, hematoxylin and eosin staining.