Fig. 2

SOCS7 regulates HGSOC cell growth both in vitro and in vivo. a The mRNA and protein levels of SOCS7 in various HGSOC cell lines and human ovarian epithelial cell line IOSE80. b Association between SOCS7 expression and cell cycle, based on GSEA analysis. c-e SOCS7 overexpression and knockdown in HGSOC cells transduced with indicated lentiviral vectors. f–h Viability and i-n cell cycle of HGSOC cells transduced with indicated lentiviral vectors. o-r CAOV3 cells transduced with pLVX-Puro-SOCS7 or blank pLVX-Puro were injected into nude mice, and SOCS7 expression levels (o), tumor volume (p), weight (q), and the immunofluorescence staining for Ki67 (r) were determined. Scale bar = 50 μm. *P < 0.05, **P < 0.01, and ***P < 0.001, in related with IOSE80, shNC or Vector