Fig. 1

Prognostic role of immune signatures in pediatric tumors. A tSNE plot of filtered normalized expression values annotated by pediatric cancer types. B tSNE plot of filtered normalized expression values annotated by ICR clusters. C Boxplot of the ICR score across pediatric tumor types. D Forest plot of the association of continuous ICR scores with survival across tumors (E) Kaplan-Meier overall survival curve for ICR High + medium (orange) versus ICR low (blue) in Osteosarcoma. F Kaplan-Meier overall survival curve for ICR High versus ICR low in high risk NBL without MYCN amplification. G Forest plot of Hazards ratio of immune subpopulations across different pediatric tumors. H Heatmap of enrichment scores of immune cells signatures. I Hazards ratio heatmap of these signatures, the color of the circle representing the HR; HR below 1 is red and above 1 is blue, the radius size representing the -log10 p value; Larger size has higher -log10 p value and more significant association with survival, the color of the background corresponding to the p value; if pink; p value is less than 0.05, if yellow; p value between 0.05 and 0.1 and the white means p value above 0.1