Fig. 4

Immune checkpoints expression across Immune subtypes. A Pan-cancer Forest plot showing HRs (overall survival) and p-values of immune checkpoint expression. B Heatmap of log2-transformed expression of immune checkpoints aggregated by the median for each immune subtype, split into activator and inhibitor and annotated by immune subtypes. C Hazard ratio heatmap of these immune checkpoints, the color of the circle representing the HR; HR below 1 is red and above 1 is blue, the radius size representing the -log10 p value; Larger size has higher -log10 p value and more significant association with survival, the color of the background corresponding to the p value; if pink; p value is less than 0.05, if yellow; p value between 0.05 and 0.1 and the white means p value above 0.1. D Violin plots showing the log2 expression of immune checkpoints across the different immune subtypes