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Fig. 9 | Journal of Experimental & Clinical Cancer Research

Fig. 9

From: Expression and activation of nuclear hormone receptors result in neuronal differentiation and favorable prognosis in neuroblastoma

Fig. 9

Graphical abstract. Activation of the three NHRs via E2, DEX, and ATRA results in profound changes in NB cells with combined ERα and GR overexpression. Cells respond by morphological changes and neurite outgrowth with upregulation of the p75NTR, SCG2, and TH neuronal differentiation markers. The three ligands also induce metabolic reprogramming manifested by increased glycolysis and accumulation of lipid droplets. Mice with xenografts from GR- and ERα-overexpressing neuroblastoma cells, where NHR signaling is activated by endogenous mouse ligands, show reduced tumor growth compared to control. Importantly, neuroblastoma patients with high levels of ERα, GR, and RARα show favorable prognosis and survival while patients with low levels of these three receptors show a poor outcome. The figure was created with Biorender.com

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