The interplay between noncoding RNA and YAP/TAZ signaling in cancers: molecular functions and mechanisms

Zhang, Yirao; Wang, Yang; Ji, Hao; Ding, Jie; Wang, Keming

doi:10.1186/s13046-022-02403-4

Journal of Experimental & Clinical Cancer Research

Table 2 lncRNAs regulate the expression of YAP/TAZ and cancer progression

From: The interplay between noncoding RNA and YAP/TAZ signaling in cancers: molecular functions and mechanisms

LncRNAs	Cancer type	Role in cancer	Key mechanisms	Functions	Reference
LUADT1	nasopharyngeal carcinoma	oncogene	lncRNA LUADT1 sponges miR-1207-5p to promote YAP/TAZ expression	promote proliferation,invasion and migration	[101]
RP11-51O6.1	colorectal cancer	oncogene	lncRNA RP11-51O6.1 sponges miR-206 to promote YAP1 expression	promote proliferation,migration and invasion	[102]
RP11-757G1.5	colorectal cancer	oncogene	lncRNA RP11-757G1.5 sponges miR-139-5p to promote YAP1 expression	promote proliferation,migration and invasion	[103]
LINC00174	colocrectal carcinoma	oncogene	LINC00174 sponges miR-1910-3p to promote TAZ expression	promote proliferation	[104]
LINC00649	gastric cancer	oncogene	LINC00649 sponges miR-16-5p to promote YAP1 expression	promote proliferation,migartion and EMT process	[105]
HCG18	gastric cancer	oncogene	lncRNA HCG18 sponges miR-141-3p to promote YAP/TAZ expression	promote viability, migration and invasion	[106]
LINC00475	glioma	oncogene	LINC00475 sponges miR-141-3p to promote YAP1 expression	promote proliferation,migration and invasion	[107]
LINC00473	glioma	oncogene	LINC00374 sponges miR-195-5p to promote YAP1 expression	promote proliferation,migration,invasion and inhibit apoptosis	[108]
BCYRN1	glioma	oncogene	lncRNA BCYRN1 sponges miR-125a-5p to promote TAZ expression	promote proliferation,migration and invasion	[109]
KCNQ1OT1	glioma	oncogene	lncRNA KCNQ1OT1 sponges miR-375 to promote YAP expression	promote proliferation,migration, invasion and EMT process	[110]
RBM5-AS1	oral squamous cell carcinoma	oncogene	lncRNA RBM5-AS1 sponges miR-1285-3p to promote YAP1 expression	promote proliferation,migration and invasion	[111]
LEF1-AS1	oral squamous cell carcinoma	oncogene	lncRNA LEF1-AS1 interacts with LAST1 and inhibit the binding of LAST1 with MOB to repress YAP phosphorylation	promote proliferation, migration, induce apoptosis	[112]
PICSAR	cutaneous squamous cell carcinoma	oncogene	lncRNA PICSAR sponges miR-125b to promote YAP1 expression	promote proliferation,invasion and inhibit apoptosis	[113]
DUXAP8	ovarian cancer	oncogene	lncRNA DUXAP8 sponges miR-590-5p to promote YAP1 expression	promote proliferation and inhibit apoptosis	[114]
LINC00857	ovarian cancer	oncogene	LINC00857 sponges miR-486-5p to promote YAP1 expression	promote proliferation,migartion,invasion and glycolysis,inhibit aoptosis	[115]
ASAP1-IT1	ovarian cancer	tumor suppressor	lncRNA ASAP1-IT1 sponge miR 2278 to promote LATS2 expression deactivating YAP1	inhibit proliferation, induce apoptosis	[116]
NOC2L-4.1	cervical cancer	oncogene	lncRNA NOC2L-4.1 sponges miR-630 to promote YAP1 expression	promote proliferation,migration	[117]
APTR	osteosarcoma	oncogene	lncRNA APTR sponges miR-132-3p to promote YAP1 expression	promote proliferation,migration and invasion,inhibit apoptosis	[118]
TUG1	renal cell carcinoma	oncogene	lncRNA TUG1 sponges to miR-9 to promote YAP1 expression	promote proliferation and migration	[119]
CCAT2	laryngeal squamous cell carcinoma	oncogene	lncRNA CCAT2 binds to YAP protein and blocks the phosphorylation of YAP induced by LATS1	promote viablity, invasion	[120]
PWAR6	pancreatic ductal adenocarcinoma	oncogene	lncRNA PWAR6 recruit EZH2 to the promoter of YAP1 to repress YAP1 expression	inhibit proliferation, invasion and migration, induce apoptosis	[121]

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ISSN: 1756-9966

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