The interplay between noncoding RNA and YAP/TAZ signaling in cancers: molecular functions and mechanisms

Table 3 circRNAs regulate the expression of YAP/TAZ and cancer progression

CircRNA	Cancer type	Role in cancer	Key mechanisms	Functions	Reference
Circ_0000511	breast cancer	oncogene	Circ_0000511 sponges miR-326 to promote TAZ expresssion	promote proliferation,migration and invasion,inhibit apoptosis	[161]
Circ_0091074	breast cancer	oncogene	Circ_0091074 sponges miR-1297 to promote TAZ expression	promote proliferation,cell cycle transition and invasion	[162]
CircFAT1	osteosarcoma	oncogene	CircFAT1 sponges miR-375 to promote YAP1 expression	promote proliferation, migration and invasion, inhibit apoptosis	[163]
Circ_0005273	breast cancer	oncogene	Circ_0005273 sponges to promote YAP1 expresssion	promote proliferation and migration	[164]
Circ_0014235	non-small cell lung cancer	oncogene	Circ_0014235 sponges miR-146b-5p to promote YAP expression	promote proliferation and Gefitinib resistance,inhibit apoptosis	[165]
Circ_0085576	clear cell renal cell carcinoma	oncogene	Circ_0085576 sponges miR-498 to promote YAP1 expresssion	promote proliferation,migration and invasion,induce apoptosis	[166]
Circ_0106714	colorectal cancer	tumor supressor	Circ_0106714 sponges miR-942-5p to promote DLG2 expression result in increasing YAP phosphorylation	inhibit proliferation, migration and invasion, induce apoptosis	[167]
Circ_0000140	oral squamous cell carcinoma	tumor suppressor	Circ_0000140 sponges miR-31 to promote LAST2 expression increasing YAP phosphorylation	inhibit proliferation, migration, invasion and EMT process, induce apoptosis	[168]

ISSN: 1756-9966