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Fig. 5 | Journal of Experimental & Clinical Cancer Research

Fig. 5

From: Circ_0004087 interaction with SND1 promotes docetaxel resistance in prostate cancer by boosting the mitosis error correction mechanism

Fig. 5

Circ_0004087 enhances BUB1 promoter activity in an SND1-dependent manner. (A) Differentially expressed genes in circ_0004087-overexpressing PCa cell lines. |log2(FC)|≥ 2, P < 0.05. (B) Enrichment analysis of potential targets of circ_0004087. (C) Differentially expressed genes in TCGA PRAD dataset. |log2(FC)|≥ 1, P < 0.05. (D) Enrichment analysis of potential oncogenes in PCa. (E) Overlapping cell cycle-related gene sets. (F) Correlation analysis for MYB and BUB1 expression in TCGA PRAD dataset. (G) Schematic diagram of dual-luciferase reporter vectors containing wild-type (BUB1 promoter) or mutant (BUB1 promoter-Mut) BUB1 promoter. (H) The activity of wild-type (BUB1 promoter) and mutant (BUB1 promoter-Mut) BUB1 promoter in PCa cells stably transfected with MYB-overexpressing or knocking-down vectors. (I) The activity of wild-type (BUB1 promoter) and mutant (BUB1 promoter-Mut) BUB1 promoter in PCa cells as indicated measured by dual-luciferase reporter assay. Statistical analysis is shown on the bar graphs. Data are presented as the mean ± SD of three independent experiments. * P < 0.05, ** P < 0.01, *** P < 0.001, **** P < 0.0001

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