Table 1 LncRNAs regulating miRNAs in prostate cancer
LncRNA | Signaling network | Major impacts | Refs |
|---|---|---|---|
TUC338 | MiRNA-466 | Acting as tumor-promoting factor TUC338 down-regulates miRNA-466 expression to increase progression of prostate cancer | [149] |
IUR | MiRNA-200/ZEB1 | Increased expression of miRNA-200 by lncRNA IUR Subsequent inhibition of ZEB1 in inhibiting cancer invasion | [140] |
BRE-AS1 | MiRNA-145-5p | Acting as tumor-suppressor factor BRE-AS1 enhances miRNA-145-5p expression to stimulate apoptosis in prostate cancer cells | [141] |
TUG1 | MiRNA-139-5p/SMC1A | Reduced miRNA-139-5p expression by lncRNA TUG1 SMC1A upregulation Triggering radio-resistance feature of prostate cancer | [126] |
HOXA-AS2 | MiRNA-509-3p/PBX3 | Enhancing progression of prostate cancer Reducing miRNA-509-3p expression via sponging to enhance PBX3 expression | [150] |
PVT1 | MiRNA-146a | Reducing expression level of miRNA-146a by triggering methylation of CpG islands Enhancing prostate cancer cell viability Apoptosis inhibition | [151] |
UCA1 | MiRNA-331-3p/EIF4G1 | Increased expression of UCA1 and EIF4G1 in prostate cancer Reduced expression of miRNA-331-3p by UCA1 via sponging Mediating radio-resistance | [152] |
SNHG1 | MiRNA-199a-3p/CDK7 | Increasing growth and survival of prostate cancer cells Triggering cell cycle progression Reducing miRNA-199a-3p expression to upregulate CDK7 | [153] |
SNHG4 | MiRNA-377/ZIC5 | Overexpression of SNHG4 in prostate cancer by SP1 Reducing miRNA-377 expression by acting as ceRNA Increasing ZIC5 expression to mediate proliferation and invasion | [125] |
OGFRP1 | MiRNA-124-3p/SARM1 | Decreasing miRNA-124-3p expression by acting as ceRNA SARM1 upregulation Mediating malignant behavior of prostate tumor cells | [154] |
KCNQ1OT1 | MiRNA-211-5p/CHI3L1 | Overexpression of lncRNA in prostate cancer cells and tissues Decreasing miRNA-211-5p levels to increase CHI3L1 levels Increasing growth and migration | [155] |
MALAT1 | MiRNA-320b/AR | Reduction in miRNA-320b expression by MALAT1 to induce AR signaling Increasing cell cycle progression | [156] |
FAM83H-AS1 | MiRNA-15a/CCNE2 | Sponging miRNA-15a to increase CCNE2 expression Promoting growth and cell cycle progression of prostate tumor | [157] |
ANRIL | Let-7a/TGF-β1/Smad | Reducing expression level of Let-7a to induce TGF-β signaling Increasing metastasis and invasion | [158] |
TTTY15 | MiRNA-29a-3p/DVL3 | Positive association with tumor progression Increasing DVL3 expression via miRNA-29a-3p down-regulation | [159] |
BLACAT1 | MiRNA-29a-3p/DVL3 | The miRNA-29a-3p expression inhibition by BLACAT1 and subsequent increase in DVL3 levels Mediating prostate tumor progression | [160] |