Table 2 An overview of lncRNAs involved in prostate cancer progression/inhibition
LncRNA | Signaling network | Remarks | Refs |
|---|---|---|---|
UNC5B-AS1 | Caspase-9 | Enhanced expression of UNC5B in prostate cancer cells and tissues Negative association between UNC5B-AS1 and caspase-9 and presence of negative feedback loop Preventing apoptosis | [338] |
GASL1 | GLUT1 | Significant difference in GASL1 expression in normal and prostate cancer tissues Reducing GLUT1 expression and increasing Bcl-2 expression Overexpression of GASL1 suppresses tumor growth and invasion | [339] |
GAS5 | - | Exposing prostate cancer cells to dexamethasone enhances expression level of GAS5 to suppress proliferation and stimulate cell cycle arrest | [340] |
EMX2OS | cGMP/PKG | Low expression of EMX2OS in prostate cancer, revealing its tumor-suppressor role Overexpression of EMX2OS and TCF12 jointly induces cGMP/PKG pathway to inhibit growth and viability of cancer cells | [341] |
UCA1 | MDM2/E-cadherin | Preventing the interaction between MDM2 and E-cadherin Increasing stability of E-cadherin Preventing aggressive behavior of prostate cancer cells | [342] |
TMPO-AS1 | - | This lncRNA can be considered as a prognostic and diagnostic tool in prostate cancer Overexpression of TMPO-AS1 is associated with undesirable prognosis Apoptosis inhibition | [343] |
NCK1-AS1 | - | Overexpression of NCK1-AS1 in prostate cancer and can be utilized for distinguishing with BPH patients | [344] |
NR2F2-AS1 | CDK4 | Acting as tumor-promoting factor Increasing expression level of CDK4 Mediating cell cycle progression | [345] |
GAS5 | - | Association of GAS5 with translational elongation, protein biosynthesis and transcription Apoptosis inhibition Increasing proliferation and cell cycle progression | [346] |
SOCS2-AS1 | TNFSF10 | Upregulation of SOCS2-AS1 in prostate cancer Down-regulation of TNFSF10 by lncRNA Apoptosis inhibition | [347] |
HOTAIR | - | HOTAIR can drive neuroendocrine differentiation of prostate cancer | [348] |
POTEF-AS1 | - | Increasing growth and cell cycle progression Inhibiting apoptosis via down-regulating TLR pathway Mediating docetaxel resistance via suppressing apoptosis | [349] |
MIR4435-2HG | FAK/Akt/β-catenin | Overexpression of MIR4435-2HG in prostate cancer cells and tissues Silencing this lncRNA prevents proliferation and invasion MIR4435-2HG cooperates with ST8SIA1 to induce FAK/Akt/β-catenin signaling, leading to prostate cancer progression | [350] |
SNHG1 | hnRNPL/EMT | Interaction of SNHG1 with hnRNPL to induce EMT in prostate cancer via E-cadherin down-regulation and vimentin upregulation Increasing migration and metastasis of cancer cells | [351] |
ARLNC1 | AR | Upregulation of ARLNC1 by AR ARLNC1 can also promote AR stabilization via RNA-RNA interaction Increasing prostate cancer progression | [352] |
LBCS | hnRNPK/AR | Interaction of LBCS with hnRNPK to suppress AR translation Low expression of LBCS is associated with poor prognosis Preventing castration resistance in prostate cancer | [353] |