Table 2 The role of adipocytes-derived exosomes in regulating BC progression
From: The pleiotropic roles of adipocyte secretome in remodeling breast cancer
Exosomes sources | Exosomes contents | Target cells | Function and mechanisms | Ref. |
|---|---|---|---|---|
IR adipocytes | TSP5 | MDA-MB-231, MCF7, T47D | Induced EMT and CSC-related gene expression in BC cells, promoted BC malignancy in type 2 diabetes | [129] |
hADSCs | N/A | MCF-7 | Promoted MCF-7 migration by activating Wnt signaling in vitro | [130] |
hADSCs | N/A | MCF-7 | Promoted MCF-7 migration, reduced BC cell apoptosis and altered the transcriptome, promoted MCF-7 growth via activating Hippo signaling pathway | [131] |
Pre-adipocytes | miR-140 | DCIS cells | Influenced CSC renewal, BC cell migration, and neoplasia through miR-140/SOX2/SOX9 axis | [132] |