Fig. 3

AEP-produced tTmod3 exists in many types of solid tumors and is highly associated with poor prognosis in patients with GBM. A Immunoblots of Tmod3, AEP and GAPDH in HGG. Tissues with obvious Tmod3 cleavage bands are marked in red. B Correlation analysis of AEP activation and cleavage of Tmod3 in tissues of HGG. Pearson r = 0.6324, P = 0.0086. C Immunoblots of Tmod3, AEP and GAPDH in LGG. D Immunoblots of Tmod3, AEP and GAPDH in normal brain tissues. E Immunoblots of Tmod3, AEP and GAPDH in hepatocellular carcinoma tissues. F Immunoblots of Tmod3, AEP and GAPDH in cervical cancer tissues. G Enhanced brain MRI images of GBM tissues with or without cleavage of Tmod3. The general extent of the tumor is circled in red. Patient 1: with high cleavage of Tmod3; Patient 2: without cleavage of Tmod3. H Kaplan–Meier survival plots showing the survival rates of the two groups of patients with or without cleavage of Tmod3. Comparisons of the survival curves were performed with Log-rank tests