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Fig. 4 | Journal of Experimental & Clinical Cancer Research

Fig. 4

From: Synaptotagmin 11 scaffolds MKK7–JNK signaling process to promote stem-like molecular subtype gastric cancer oncogenesis

Fig. 4

SYT11-associated genes. A, Venn diagrams of up-regulated genes in GC patient tissues or GC cells expressing high levels of SYT11 (fold change > 1.5; p < 0.001). B, Genes that are highly correlated with SYT11. The expression correlation of SYT11 with THBS4, JAM3, Vimentin and ANGPTL2 was examined in the YSH cohort (n = 527) and ACRG cohort (GSE66229; n = 300). C, IHC analysis of THBS4, Vimentin, ANGPTL2 and SYT11 in GC tissues (US Biomax). More THBS4, Vimentin and ANGPTL2 were present in SYT11-high tissues. D, mRNA level of the indicated genes in SYT11-high or SYT11-low GC cell lines. E, Kaplan-Meier survival curves comparing high or low SYT11 expression and the genes ANGPTL2, THBS4, JAM3 and Vimentin in intestinal-type and diffuse-type GC

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