Fig. 2From: POLE/POLD1 mutation and tumor immunotherapyCorrelation between POLE/POLD1 mutation and TMB and MSI. The TMB of POLE/POLD1 mutations referred to as ultra-high mutation, which is associated with MSS. However, not all POLE/POLD1 mutations are MSS. Tumors with high TMB usually have stronger T lymphocyte infiltration and can exert stronger anti-tumor activityBack to article page