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Fig. 2 | Journal of Experimental & Clinical Cancer Research

Fig. 2

From: CD147 mediates epidermal malignant transformation through the RSK2/AP-1 pathway

Fig. 2

CD147 promotes the development of DMBA/TPA-induced skin carcinogenesis in transgenic mice. A Schematic diagram of the DMBA/TPA-induced skin carcinogenesis mouse model. EpiCD147-OE mice and EpiCD147-WT mice were treated with DMBA and TPA as described in the Materials and Methods. B-C Tumor volume (B) and number (C) were measured every week as described in the Materials and Methods. The tumor growth curves are shown as the mean tumor volume ± SD. The significance of differences was evaluated using one-way ANOVA. D-E Representative images of induced mouse models (D) and H&E staining of tumors (E) are shown at 26 weeks after stimulation. Scale bar = 1 cm. F CD147 promotes the proliferation of cSCC cells. Immunohistochemical staining of PCNA was performed as described in the Materials and Methods. Representative images were taken (F left panel), and bar chart graphs of the PCNA positive rate (%) (F right panel) are shown. Data are presented as the mean ± SD (n = 4). The significance of differences was evaluated using Student’s t-test

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