Fig. 2

A PCA was performed for 11 AML samples, 7 T-ALL samples, 8 B-ALL samples, and 3 AML cell lines based on the H3K27ac signals identified in each sample. Each circle represents a sample, and each color represents the type of sample. B Cluster analysis results of 11 AML samples, 7 T-ALL samples, 8 B-ALL samples, and 3 AML cell lines based on the H3K27ac signals identified in each sample. C genes commonly associated with super-enhancers in AML samples were subjected to gene ontology analysis. The significant categories are shown. D the ChIP-Seq gene tracks represent the H3K27ac signal in AML cell lines (NB4, MV4–11, and THP1) and 11 AML samples at the MPO gene loci. The super-enhancers are shown as green boxes. E the ChIP-Seq gene tracks represent the H3K27ac signal in AML cell lines (NB4, MV4–11, and THP1) and 11 AML samples at the SPI1 gene loci. The super-enhancers are shown as green boxes. F the ChIP-Seq gene tracks represent the H3K27ac signal in AML cell lines (NB4, MV4–11, and THP1) and 11 AML samples at the ZFP36l2 gene loci. The super-enhancers are shown as green boxes