Fig. 4

A Volcano Plot of RNA-seq results for NB4 cell line in either the absence or presence of GNE-987 (25 nM, 24 h). B Gene oncology enrichment analysis results of all DEGs. C Venn diagram of genes associated with super-enhancers and sensitive to GNE-987 in AML cells. D Super-enhancer status at 20 gene loci in 11 AML samples and NB4 cells (left and middle). Super-enhancers are shown in red. A heatmap represents the relative expression levels of the 20 genes after GNE-987 treatment in NB4 cells (right). E qRT-PCR results of 16 super-enhancer-associated genes in NB4 cell line treated with GNE-987