Table 1 A list of circRNAs related to GC metastasis

circTHBS1

hsa_circ_0034536

Up

Enhancer

Modulate the miR-204-5p/INHBA axis and interact with the RBP, HuR

[48]

circCCDC66

hsa_circ_0001313

Up

Enhancer

Activate c-Myc/TGF-β signaling pathway

[49]

circ_0001829

hsa_circ_0001829

Up

Enhancer

Sponge miR-155-5p to upregulate SMAD

[50]

circOXCT1

hsa_circ_0004873

Down

Repressor

Sponge miR-136 to upregulate SMAD4

[51]

circAXIN1

hsa_circ_0005838

Up

Enhancer

Encode a novel protein, AXIN1-295aa

[52]

circFGD4

hsa_circ_0000390

Down

Repressor

Sponge miR-532-3p to upregulate APC

[53]

circREPS2

hsa_circ_0139996

Down

Repressor

Sponge miR-558 to upregulate RUNX3

[54]

circAKT3

hsa_circ_0000199

Up

Enhancer

Sponge miR-198 to upregulate PIK3R1

[55]

circ_0023409

hsa_circ_0023409

Up

Enhancer

Sponge miR-542-3p to upregulate IRS4

[56]

ciRS-7

hsa_circ_0001946

Up

Enhancer

Sponge miR-7 to upregulate PTEN

[57]

circTNPO3

hsa_circ_0001741

Down

Repressor

Interact with the RBP, IGF2BP3

[58]

circFNDC3B

hsa_circ_0006156

Up

Enhancer

Interact with the RBP, IGF2BP3

[59]

circ_100876

hsa_circ_0023404

Up

Enhancer

Sponge miR-665 to upregulate YAP1

[60]

circPRRX1

hsa_circ_0004370

Up

Enhancer

Sponge miR-665 to upregulate YWHAZ

[61]

circRanGAP1

hsa_circ_0063526

Up

Enhancer

Regulate the miR-877-3p/VEGFA axis

[62]

circ_0044366

hsa_circ_0044366

Up

Enhancer

Sponge miR-29a to upregulate VEGF

[63]

circURI1

hsa_circ_0000921

Up

Repressor

Interact with the splicing factor hnRNPM

[64]

ebv-circLMP2A

-

Up

Enhancer

Form a positive feedback loop with HIF1α

[65]

circNRIP1

hsa_circ_0004771

Up

Enhancer

Sponge miR-149-5p to upregulate AKT1

[66]

circNEK9

hsa_circ_0032683

Up

Enhancer

Sponge miR-409-3p to upregulate MAP7

[67]

circRELL1

hsa_circ_0001400

Down

Repressor

Sponge miR-637 to upregulate EPHB3

[68]

circSHKBP1

hsa_circ_0000936

Up

Enhancer

Modulate the miR-582-3p/HuR/VEGF axis and interact with HSP90

[69]

circMRPS35

hsa_circ_0000384

Down

Repressor

Recruit the histone modifier, KAT7

[70]

circMAPK1

hsa_circ_0004872

Down

Repressor

Encode a MAPK1-109aa protein

[71]

circRPL15

hsa_circ_0064574

Up

Enhancer

Sponge miR-502-3p to upregulate OLFM4

[72]

circUBE2Q2

hsa_circ_0005151

Up

Enhancer

Modulate the miR-370-3p/STAT3 axis

[73]

circAGO2

hsa_circ_0135889

Up

Enhancer

Interact with the RBP, HuR

[74]

circHuR

hsa_circ_0049027

Down

Repressor

Transcriptionally repression in cis

[75]