Table 4 Other TME stress-regulated ncRNAs and their roles during cancer progression
From: Noncoding RNAs as sensors of tumor microenvironmental stress
NcRNAs | Expression upon stress conditions | Regulatory mechanisms | Functions | Cancer types | References |
|---|---|---|---|---|---|
lncRNA GOLGA2P10 | Up-regulated under ER stress | PERK/ATF4/CHOP pathway | Regulate cancer cell apoptosis | Hepatocellular carcinoma | [145] |
lncRNA MALAT1 | Up-regulated under ER stress | IRE1/XBP1 and PERK/elF2α/ATF4 pathways | Promote cancer metastasis | Colorectal cancer | [146] |
miR-23a-3p | Up-regulated under ER stress | N.A | Promote immune escape | Hepatocellular carcinoma | [147] |
lncRNA HISLA | Up-regulated under acidosis | ERK/ELK1 signaling | Promote aerobic glycolysis and chemoresistance | Breast cancer | [148] |