Fig. 7

Ixa + Dina combination impairs tumor growth in HCC PDXs. A Representative gross tumor images of HCC PDX1 after treatment with vehicle, ixazomib (7 mg/kg), dinaciclib (5 mg/kg), Ixa + Dina, and sorafenib (30 mg/kg). Scale bar = 1 cm. B and C Tumor volumes (B) and growth rates (C) of PDX1 tumors after drug treatment. Data presented as mean ± SD, n = 5 to 9. ***, P < 0.001 compared to Ixa + Dina group. D Body weight changes of mice bearing HCC PDX1 tumors over the course of drug treatment. Data presented as mean ± SD, n = 5 to 9. E Representative gross tumor images of HCC PDX11 after treatment with vehicle, ixazomib (7 mg/kg), dinaciclib (5 mg/kg), Ixa + Dina, and sorafenib (30 mg/kg). Scale bar = 1 cm. F and G PDX11 tumor volumes (F) and growth rates (G) after drug treatments. Data presented as mean ± SD, n = 7 to 9. **, P < 0.01; ***, P < 0.001 compared to Ixa + Dina group. H Mean body weight of PDX11 tumor-bearing mice during the course of drug treatment. Data presented as mean ± SD, n = 7 to 9. All statistical analyses were performed using two-tailed Student’s t test